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Posts Tagged "cancer"

Combining the Pieces in Microfluidics for Personalized Cancer Therapy

Combining the Pieces in Microfluidics for Personalized Cancer Therapy

Personalized cancer therapy is a treatment strategy based on the ability to predict which patients are more likely to respond to specific cancer therapies1. Different factors such as tumor biophysical markers, tumor site, patient genetic factors, and characteristics need to be considered in determining a specific therapy for a patient. Tumor biophysical markers including phenotypes and genotypes are associated with patient prognosis and response to therapy as phenotypes like size, shape, stiffness of individual cells within a tumor can be correlated with the state of the disease and genotypic information from DNA, RNA and protein sequencing can reveal genomic alterations. Moreover, patient genetic factors are also important as they can be associated with drug metabolism, drug toxicity, and overall drug response. (more…)

Microfluidic Environments Nurture Stem Cells on Their Journey Toward Commercialization

Microfluidic Environments Nurture Stem Cells on Their Journey Toward Commercialization

The name “stem” cells came from plant stems, which, despite their tiny size, have the capacity to produce flowers, leaves, branches, fruit, vegetables, and gigantic trees. In the same way, stem cells, although microscopic, contain the potential to develop into different body parts — to repair or replace diseased or injured cells. Stem cells can differentiate, which means they can become a retina or pancreas cells, skin cells or shin cells, cells specific to the nose or to the toes. Stem cells are sustained by a microfluidic environment of supporting blood vessels and channels for other fluids. And a stem cell’s microfluidic environment influences the decision about what body part it will become. (more…)

Microfluidics Technologies for Circulating Tumor Cell Analysis: Opportunities and Challenges

Microfluidics Technologies for Circulating Tumor Cell Analysis: Opportunities and Challenges

Circulating tumor cells (CTCs) are tumor cells that are shed from cancerous tumors into the circulatory systems. CTCs are present in early-stage cancers and are reported to relate to disease prognosis. In recent years, CTCs have drawn increasing attention in both academic and industrial research, as they offer opportunities for the early detection, monitoring, treatment evaluation of cancer and its metastasis 1. (more…)