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Archive for April, 2019

Managing Real-State on Centrifugal Microfluidic Platforms

Managing Real-State on Centrifugal Microfluidic Platforms

Centrifugal microfluidic platforms, also called compact microfluidic biodisks or compact disks (CD), have been around for almost four decades and have seen a surge in technology advancement in the last decade1. CDs are used in rapid immunoassaying and clinical biochemistry for blood diagnostics. They are used as micro total analysis systems (μTAS), in which several individual assays are embedded and run simultaneously on a single chip. They operate on simple inexpensive motors programmed for hands-free control and do not require external actuators such as magnets or surface treatments. Basically, CDs are great, and this article should end here. Unfortunately, there is a catch: due to unidirectional (radial) centrifugal forces, CDs run out of real estate faster than non-rotating microfluidic devices. (more…)

Combining the Pieces in Microfluidics for Personalized Cancer Therapy

Combining the Pieces in Microfluidics for Personalized Cancer Therapy

Personalized cancer therapy is a treatment strategy based on the ability to predict which patients are more likely to respond to specific cancer therapies1. Different factors such as tumor biophysical markers, tumor site, patient genetic factors, and characteristics need to be considered in determining a specific therapy for a patient. Tumor biophysical markers including phenotypes and genotypes are associated with patient prognosis and response to therapy as phenotypes like size, shape, stiffness of individual cells within a tumor can be correlated with the state of the disease and genotypic information from DNA, RNA and protein sequencing can reveal genomic alterations. Moreover, patient genetic factors are also important as they can be associated with drug metabolism, drug toxicity, and overall drug response. (more…)