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Archive for March, 2019

Droplet-Based Single-Cell Sequencing

Droplet-Based Single-Cell Sequencing

Cells form the basic unit of life and can broadly vary in biological structure and function. Nucleic acids encode the information of life by programming cellular functions at the level of transcription for specific biological outcomes. Single-cell genomics provides a window to characterize the identity and function of cells. Drawbacks of the technique include a lack of practical ease and scale. Sequencing information provides a map to understand the properties of a single cell; including the type, state and nature of its biology during its regular function and during pathogenesis. Since all cells are not alike, it is increasingly important to recognize the difference between cells for deeper insight into their behavior for tailored treatments in personalized medicine. It is possible to probe the properties of individual cells in the lab using advanced single-cell sequencing techniques. (more…)

Microfluidic Heat Exchanger, a Unique Solution for Cooling of the Latest Electronic Devices

Microfluidic Heat Exchanger, a Unique Solution for Cooling of the Latest Electronic Devices

When a lot of electro-mechanical systems have been miniaturized and integrated by compact design, thermal management in a small volume should be simultaneously considered. As the devices or systems become smaller, heat flux increases in general. Therefore, an effective cooling strategy for the micro-devices is required especially when the cooling target is made from microfabrication processes. The microfluidic heat exchanger is one of the most promising devices for cooling down the electronic systems because it can be also made by the microfabrication processes1. This device which is also called microchannel heat sink has been considered as an effective heat removal tool and has caught much attention during the past decades, due to its advantages including high heat transfer performance, mild pressure loss and easy fabrication2. (more…)