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Organs-on-a-Chip revolution: Standing tall on the shoulder of giants

Organs-on-a-Chip revolution: Standing tall on the shoulder of giants

Drug discovery is a lengthy and costly endeavor. In fact, the cost of drug development has been rising year after year as result of a lack of physiological models that can accurately predict the effect of a drug in humans. Therefore, risky drugs may enter human clinical trials while promising drugs might be eliminated at early stages; both scenarios lead to a sizable financial loss. Organ-on-a-chip devices have emerged to combat this, and are poised to fill this gap where the conventional cell-based assays and animal testing    fail1,2. These technologies build on sophisticated microfluidic systems to culture human cells in a precisely controlled microenvironment to coordinate cells to work together and to recapitulate organ-level function that would otherwise be difficult to mimic in a traditional monolayer culture environment. The ultimate goal is to accurately model human physiology for precision drug testing.

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A manufacturer’s 2 cents on developing microfluidic products

A manufacturer’s 2 cents on developing microfluidic products

Everyday clients share their microfluidic designs or products with contract manufacturing companies. Interestingly the designs can be classified to two types, let’s call them Type A or B, based on whether they exploit micron-size specific behavior of fluids or not. These small scale phenomena include surface tension, electrical, magnetic or shear force, etc… which may behave differently in a 30 micron dia. channel compared to a 1mm dia. channel for similar designs.

Type A devices exploit the micron scale behavior to achieve a novel function. A Type A product offers something new that probably is not feasible if the design is scaled 10 times larger. Type A designs are therefore innovative or perhaps disruptive. On the other hand, Type B devices offer to miniaturize, integrate or automate existing fluidic products or processes. The value proposition for type B products may include “cheaper”, “faster” or “more accurate” words.

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