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Archive for March, 2018

Senso-fluidics: Continuous monitoring using sensors in microfluidics

Senso-fluidics: Continuous monitoring using sensors in microfluidics

Humans have always been fascinated with reverse engineering, whether to create Frankenstein or artificial organs. This science fiction is slowly becoming a reality using the organ-on-chip and tissue engineering technology. In organ-on-chip technology, the physiological function of a human organ is closely mimicked inside a microfluidic channel. Tissue engineering may involve bio-printing of living cells inside a scaffold to mimic a whole organ. Both these technologies offer great promise for developing personalized medicine and studying disease models. The successful use of this technology will depend on the ability to maintain healthy cell environment and monitor biological processes inside microfluidic channels for an extended period of time (~2-4 weeks). By integrating sensors inside microfluidic channels, these parameters can be continuously monitored. The advantages of integrating sensors into microfluidic channels are: (more…)

Seeing is believing: Tissue-chips on the quest to end blindness

Seeing is believing: Tissue-chips on the quest to end blindness

In 2007, Doug Oliver nearly hit two pedestrians while driving his car, and then turned a corner and almost hit a third. He had not seen the pedestrians at all. A police officer gave him two choices: hand over your driver’s license or see an eye doctor. The doctor gave a chilling diagnosis: “At 45, I was legally blind. I went into shock,” Oliver said.

Oliver was born with good eyesight, but due to a hereditary condition, over a decade he had gradually lost much of his vision. For years his sight had been worsening until he underwent experimental stem cell surgery in a Florida-based treatment study. His vision loss was reversed by that surgery in 2015. “I went from legally blind to legal-to-drive in eight weeks,” said the Nashville, Tenn., man. (more…)